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Spite and virulence in the bacterium Pseudomonas aeruginosa.

机译:铜绿假单胞菌的毒力和毒性。

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摘要

Social interactions within populations of pathogenic microbes may play an important role in determining disease virulence. One such ubiquitous interaction is the production of anticompetitor toxins; an example of a spiteful behavior, because it results in direct fitness costs to both the actor and recipient. Following from predictions made by mathematical models, we carried out experiments using the bacterium Pseudomonas aeruginosa to test under what social conditions toxin (bacteriocin) production is favored and how this in turn affects virulence in the larvae of the wax moth Galleria mellonella. Consistent with theory, we found that the growth of bacteriocin producers relative to sensitive non-producers is maximized when toxin producers are at intermediate frequencies in the population. Furthermore, growth rate and virulence in caterpillars was minimized when bacteriocin producers have the greatest relative growth advantage. These results suggest that spiteful interactions may play an important role in the population dynamics and virulence of natural bacterial infections.
机译:病原微生物种群内的社会互动可能在确定疾病毒力中起重要作用。这样一种普遍存在的相互作用是产生抗竞争者毒素。恶意行为的一个例子,因为它会导致演员和接受者直接承担健身费用。根据数学模型做出的预测,我们使用铜绿假单胞菌细菌进行了实验,以测试在哪种社会条件下有利于毒素(细菌素)的生产,以及这又如何影响蜡蛾蛾幼虫的毒力。与理论一致,我们发现,当毒素生产者处于人群中的中等频率时,细菌素生产者相对于敏感的非生产者的生长就达到了最大化。此外,当细菌素生产者具有最大的相对生长优势时,毛虫的生长速度和毒力也将降至最低。这些结果表明,恶意互动可能在种群动态和天然细菌感染的毒力中发挥重要作用。

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